ORMDL3/GSDMB genotype as a risk factor for early-onset adult asthma is linked to total serum IgE levels but not to allergic sensitization

ORMDL3/GSDMB genotype as a risk factor for early-onset adult asthma is linked to total serum IgE levels but not to allergic sensitization

Background: An orosomucoid-like 3 (ORMDL3)/gasdermin B (GSDMB) gene locus on chromosome 17q is consistently associated with childhood-onset asthma, which is highly atopic. As some evidence suggests the relationship between asthma and allergic sensitization reflects asthma patient susceptibility to a...

Full description

Bibliographic Details
Main Authors: Haruna Kitazawa, Hironori Masuko, Jun Kanazawa, Rie Shigemasa, Kentaro Hyodo, Hideyasu Yamada, Yohei Yatagai, Yoshiko Kaneko, Hiroaki Iijima, Takashi Naito, Takefumi Saito, Emiko Noguchi, Satoshi Konno, Tomomitsu Hirota, Mayumi Tamari, Tohru Sakamoto, Nobuyuki Hizawa
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Allergology International
Subjects:
Asthma phenotype
Early-onset asthma
Genetics
Immunoglobulin E (IgE)
ORMDL3/GSDMB
Online Access:http://www.sciencedirect.com/science/article/pii/S1323893020300599

Internet

http://www.sciencedirect.com/science/article/pii/S1323893020300599

Similar Items