Regulatory T cells provide chondroprotection through increased TIMP1, IL-10 and IL-4, but cannot mitigate the catabolic effects of IL-1β and IL-6 in a tri-culture model of osteoarthritis

Regulatory T cells provide chondroprotection through increased TIMP1, IL-10 and IL-4, but cannot mitigate the catabolic effects of IL-1β and IL-6 in a tri-culture model of osteoarthritis

Objective: To gain insight into Treg interactions with synovial tissues in early OA, an equine tri-culture model of OA was used to test the hypothesis that Tregs, in the absence of T Helper 17 ​cells, are sufficient to resolve inflammation elicited by IL-1β. Methods: To model normal and OA joints, s...

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Bibliographic Details
Main Authors: Laura E. Keller, Elia D. Tait Wojno, Laila Begum, Lisa A. Fortier
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Osteoarthritis and Cartilage Open
Subjects:
Osteoarthritis
Regulatory T cells
T helper 17 ​cells
Interleukin 6
Interleukin 10
TIMP1
Online Access:http://www.sciencedirect.com/science/article/pii/S266591312100056X

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http://www.sciencedirect.com/science/article/pii/S266591312100056X

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