Interneurons secrete prosaposin, a neurotrophic factor, to attenuate kainic acid-induced neurotoxicity

Interneurons secrete prosaposin, a neurotrophic factor, to attenuate kainic acid-induced neurotoxicity

Prosaposin (PS) is a secretory neurotrophic factor, as well as a regulator of lysosomal enzymes. We previously reported the up-regulation of PS and the possibility of its axonal transport by GABAergic interneurons after exocitotoxicity induced by kainic acid (KA), a glutamate analog. In the present...

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Bibliographic Details
Main Authors: Hiroaki Nabeka, Shouichiro Saito, Xuan Li, Tetsuya Shimokawa, Md. Sakirul Islam Khan, Kimiko Yamamiya, Soichiro Kawabe, Takuya Doihara, Fumihiko Hamada, Naoto Kobayashi, Seiji Matsuda
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:IBRO Reports
Subjects:
Interneurons transport
Neurotrophic factor
Neuroprotection
Prosaposin
Kainic acid
Online Access:http://www.sciencedirect.com/science/article/pii/S2451830117300201

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http://www.sciencedirect.com/science/article/pii/S2451830117300201

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