Molecular modelling assisted design of napthalimide-dihydropyrimidinone conjugates as potential cytotoxic agents

Molecular modelling assisted design of napthalimide-dihydropyrimidinone conjugates as potential cytotoxic agents

A molecular modelling assisted design of napthalimide-dihydropyrimidinone conjugates as potential cytotoxic agents based on a lead molecule (elinafide) is described. One of the napthalimide moiety and the amino groups in the lead molecule are replaced with dihydropymidinone and methylene motifs, res...

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Bibliographic Details
Main Authors: M. Shaheer Malik, Syed Farooq Adil, Zaki S. Seddigi, Moataz Morad, Rabab S. Jassas, Ismail I. Thagafi, Hatem M. Altass, Qazi Mohammad Sajid Jamal, Syed Riyaz, Reem I. Alsantali, Abdulrahman A. Al-Warthan, Mohammad Azam Ansari, Saleh A. Ahmed
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Journal of Saudi Chemical Society
Subjects:
Bisnaphthalimides
Dihydropyrimidinone
Molecular modelling
DNA intercalation
Anticancer agents
Online Access:http://www.sciencedirect.com/science/article/pii/S1319610321000314

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http://www.sciencedirect.com/science/article/pii/S1319610321000314

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