Functional Analysis of KIT Gene Structural Mutations Causing the Porcine Dominant White Phenotype Using Genome Edited Mouse Models

Functional Analysis of KIT Gene Structural Mutations Causing the Porcine Dominant White Phenotype Using Genome Edited Mouse Models

The dominant white phenotype in pigs is thought to be mainly due to a structural mutation in the KIT gene, a splice mutation (G > A) at the first base in intron 17 which leads to the deletion of exon 17 in the mature KIT mRNA. However, this hypothesis has not yet been validated by functional...

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Bibliographic Details
Main Authors: Guanjie Sun, Xinyu Liang, Ke Qin, Yufeng Qin, Xuan Shi, Peiqing Cong, Delin Mo, Xiaohong Liu, Yaosheng Chen, Zuyong He
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Genetics
Subjects:
KIT
porcine coat color
melanocyte
mouse model
exon 17 deletion
CDS duplication
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00138/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2020.00138/full

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