Pressure Overload in Mice With Haploinsufficiency of Striated Preferentially Expressed Gene Leads to Decompensated Heart Failure

Pressure Overload in Mice With Haploinsufficiency of Striated Preferentially Expressed Gene Leads to Decompensated Heart Failure

Striated preferentially expressed gene (Speg) is a member of the myosin light chain kinase family of proteins. Constitutive Speg deficient (Speg−/−) mice develop a dilated cardiomyopathy, and the majority of these mice die in utero or shortly after birth. In the present study we assessed the importa...

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Bibliographic Details
Main Authors: Chang Shu, He Huang, Ying Xu, Marcello Rota, Andrea Sorrentino, Yuan Peng, Robert F. Padera, Virginia Huntoon, Pankaj B. Agrawal, Xiaoli Liu, Mark A. Perrella
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Physiology
Subjects:
myosin light chain kinase
striated preferentially expressed gene
haploinsufficiency
pressure overload
decompensated heart failure
fibrosis
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.00863/full

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https://www.frontiersin.org/article/10.3389/fphys.2018.00863/full

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