A Novel MLH1 Initiation Codon Mutation (c.3G>T) in a Large Chinese Lynch Syndrome Family with Different Onset Age and mRNA Expression Level

A Novel MLH1 Initiation Codon Mutation (c.3G>T) in a Large Chinese Lynch Syndrome Family with Different Onset Age and mRNA Expression Level

Lynch syndrome is a genetically and clinically heterogeneous disorder; it is caused by a germline mutation in DNA mismatch repair (MMR) genes. Individuals with a heterozygous mutation in MLH1 have an increased risk for developing colorectal cancer. Here we described a 5-generation Chinese Lynch synd...

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Bibliographic Details
Main Authors: Yanni Zhang, Huishuang Chen, Zhiyu Peng, Santasree Banerjee, Wei Li, Zhaolong Zhao, Jianbin Sun, Jian Lv, Hui Huang, Ru Bai, Keke Lin, Zhongxin Li
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2018/1460835

Internet

http://dx.doi.org/10.1155/2018/1460835

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