Looking for the LOAEL or NOAEL Concentration of Nickel-Oxide Nanoparticles in a Long-Term Inhalation Exposure of Rats

Looking for the LOAEL or NOAEL Concentration of Nickel-Oxide Nanoparticles in a Long-Term Inhalation Exposure of Rats

Rats were exposed to nickel oxide nano-aerosol at a concentration of 2.4 ± 0.4 µg/m<sup>3</sup> in a “nose only” inhalation setup for 4 h at a time, 5 times a week, during an overall period of 2 weeks to 6 months. Based on the majority of the effects assessed, this kind of exposure may b...

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Bibliographic Details
Main Authors: Boris A. Katsnelson, Ivan N. Chernyshov, Svetlana N. Solovyeva, Ilzira A. Minigalieva, Vladimir B. Gurvich, Irene E. Valamina, Oleg H. Makeyev, Renata R. Sahautdinova, Larisa I. Privalova, Anastasia E. Tsaregorodtseva, Artem V. Korotkov, Eugene A. Shuman, Vladimir G. Panov, Marina P. Sutunkova
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
nickel oxide nanoparticles
inhalation exposure
pulmonary and systemic toxicity
genotoxicity
allergic sensitization
Online Access:https://www.mdpi.com/1422-0067/22/1/416

Internet

https://www.mdpi.com/1422-0067/22/1/416

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