A research pathway for the study of the delivery and disposition of nebulised antibiotics: an incremental approach from in vitro to large animal models

A research pathway for the study of the delivery and disposition of nebulised antibiotics: an incremental approach from in vitro to large animal models

Abstract Background Nebulised antibiotics are frequently used for the prevention or treatment of ventilator-associated pneumonia. Many factors may influence pulmonary drug concentrations with inaccurate dosing schedules potentially leading to therapeutic failure and/or the emergence of antibiotic re...

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Bibliographic Details
Main Authors: Jayesh A. Dhanani, Jeremy Cohen, Suzanne L. Parker, Hak-Kim Chan, Patricia Tang, Benjamin J. Ahern, Adeel Khan, Manoj Bhatt, Steven Goodman, Sara Diab, Jivesh Chaudhary, Jeffrey Lipman, Steven C. Wallis, Adrian Barnett, Michelle Chew, John F. Fraser, Jason A. Roberts
Format: Article
Language:English
Published: SpringerOpen 2018-07-01
Series:Intensive Care Medicine Experimental
Subjects:
Ventilator-associated pneumonia
Nebulised antibiotics
Inhaled mass
Particle size distribution
Regional drug distribution
Microdialysis
Online Access:http://link.springer.com/article/10.1186/s40635-018-0180-7

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http://link.springer.com/article/10.1186/s40635-018-0180-7

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