An approach to design potent anti-Alzheimer’s agents by 3D-QSAR studies on fused 5,6-bicyclic heterocycles as γ-secretase modulators using kNN–MFA methodology

An approach to design potent anti-Alzheimer’s agents by 3D-QSAR studies on fused 5,6-bicyclic heterocycles as γ-secretase modulators using kNN–MFA methodology

Alzheimer’s disease (AD) is a chronic neurodegenerative disease. Current therapies of AD are only symptomatic, therefore the need for the development of new therapies to treat Alzheimer’s disease effectively. To achieve this objective quantitative structure–activity relationship (QSAR) studies were...

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Bibliographic Details
Main Authors: Kamlendra Singh Bhadoriya, Mukesh C. Sharma, Smita Sharma, Shailesh V. Jain, Mandar H. Avchar
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Arabian Journal of Chemistry
Subjects:
Alzheimer’s disease
γ-Secretase modulators
Fused 5,6-bicyclic heterocycles
3D-QSAR
kNN–MFA
Hydrophobic and steric descriptors
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535213000348

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http://www.sciencedirect.com/science/article/pii/S1878535213000348

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