TCam-2 Cells Deficient for SOX2 and FOXA2 Are Blocked in Differentiation and Maintain a Seminoma-Like Cell Fate In Vivo

TCam-2 Cells Deficient for SOX2 and FOXA2 Are Blocked in Differentiation and Maintain a Seminoma-Like Cell Fate In Vivo

Testicular germ cell tumors (GCTs) are very common in young men and can be stratified into seminomas and non-seminomas. While seminomas share a similar gene expression and epigenetic profile with primordial germ cells, the stem cell population of the non-seminomas, the embryonal carcinoma (EC), rese...

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Bibliographic Details
Main Authors: Daniel Nettersheim, Saskia Vadder, Sina Jostes, Alena Heimsoeth, Hubert Schorle
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Cancers
Subjects:
germ cell tumors
seminoma
embryonal carcinoma
reprogramming
microenvironment
SOX2
FOXA2
Online Access:https://www.mdpi.com/2072-6694/11/5/728

Internet

https://www.mdpi.com/2072-6694/11/5/728

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