Alteration of tumor suppressor BMP5 in sporadic colorectal cancer: a genomic and transcriptomic profiling based study

Alteration of tumor suppressor BMP5 in sporadic colorectal cancer: a genomic and transcriptomic profiling based study

Abstract Background Although the genetic spectrum of human colorectal cancer (CRC) is mainly characterized by APC, KRAS and TP53 mutations, driver genes in tumor initiation have not been conclusively demonstrated. In this study, we aimed to identify novel markers for CRC. Methods We performed exome...

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Bibliographic Details
Main Authors: Erfei Chen, Fangfang Yang, Hongjuan He, Qiqi Li, Wei Zhang, Jinliang Xing, Ziqing Zhu, Jingjing Jiang, Hua Wang, Xiaojuan Zhao, Ruitao Liu, Lei Lei, Jing Dong, Yuchen Pei, Ying Yang, Junqiang Pan, Pan Zhang, Shuzhen Liu, Le Du, Yuan Zeng, Jin Yang
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Molecular Cancer
Subjects:
BMP5
Tumor suppressor
Loss of function mutation
Driver gene
Sporadic colorectal cancer
Online Access:http://link.springer.com/article/10.1186/s12943-018-0925-7

Internet

http://link.springer.com/article/10.1186/s12943-018-0925-7

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