Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation.

Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation.

A remarkable characteristic of the human major histocompatibility complex (MHC) is its extreme genetic diversity, which is maintained by balancing selection. In fact, the MHC complex remains one of the best-known examples of natural selection in humans, with well-established genetic signatures and b...

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Bibliographic Details
Main Authors: Aida M Andrés, Megan Y Dennis, Warren W Kretzschmar, Jennifer L Cannons, Shih-Queen Lee-Lin, Belen Hurle, NISC Comparative Sequencing Program, Pamela L Schwartzberg, Scott H Williamson, Carlos D Bustamante, Rasmus Nielsen, Andrew G Clark, Eric D Green
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-10-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2954825?pdf=render

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http://europepmc.org/articles/PMC2954825?pdf=render

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