Possible Alterations in β-Synuclein, the Non-Amyloidogenic Homologue of α-Synuclein, during Progression of Sporadic α-Synucleinopathies

Possible Alterations in β-Synuclein, the Non-Amyloidogenic Homologue of α-Synuclein, during Progression of Sporadic α-Synucleinopathies

α-Synucleinopathies are neurodegenerative disorders that are characterized by progressive decline of motor and non-motor dysfunctions. α-Synuclein (αS) has been shown to play a causative role in neurodegeneration, but the pathogenic mechanisms are still unclear. Thus, there are no radical therapies...

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Bibliographic Details
Main Authors: Makoto Hashimoto, Kazunari Sekiyama, Akio Sekigawa, Masayo Fujita, Yoshiki Takamatsu
Format: Article
Language:English
Published: MDPI AG 2012-09-01
Series:International Journal of Molecular Sciences
Subjects:
α-synucleinopathies
α-synuclein
β-synuclein
dementia with Lewy bodies
toxic gain of function
Online Access:http://www.mdpi.com/1422-0067/13/9/11584

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http://www.mdpi.com/1422-0067/13/9/11584

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