Induction of HMG CoA reductase by the administration of 20,25-diazacholesterol

Induction of HMG CoA reductase by the administration of 20,25-diazacholesterol

This paper describes the direct examination of HMG CoA reductase activity in rats treated with 20,25-diazacholesterol. Conversion of acetyl CoA and HMG CoA to mevalonate increased to over 200% of control values in the microsomes and in the 12,000 g supernatant of liver homogenates after 5 days of tr...

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Bibliographic Details
Main Authors: R Langdon, S El-Masry, R E Counsell
Format: Article
Language:English
Published: Elsevier 1977-01-01
Series:Journal of Lipid Research
Subjects:
feedback repression
rate-limiting step
cholesterol biosynthesis
rat liver microsomes
7-ketocholesterol
hypocholesterolemic agent
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520417109

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http://www.sciencedirect.com/science/article/pii/S0022227520417109

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