Systems Approach to Pathogenic Mechanism of Type 2 Diabetes and Drug Discovery Design Based on Deep Learning and Drug Design Specifications

Systems Approach to Pathogenic Mechanism of Type 2 Diabetes and Drug Discovery Design Based on Deep Learning and Drug Design Specifications

In this study, we proposed a systems biology approach to investigate the pathogenic mechanism for identifying significant biomarkers as drug targets and a systematic drug discovery strategy to design a potential multiple-molecule targeting drug for type 2 diabetes (T2D) treatment. We first integrate...

Full description

Bibliographic Details
Main Authors: Shen Chang, Jian-You Chen, Yung-Jen Chuang, Bor-Sen Chen
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
type 2 diabetes (T2D)
pathogenic mechanism
deep neural network (DNN)-based DTI model
pathogenic biomarkers
drug design specification
multiple-molecule targeting drug
Online Access:https://www.mdpi.com/1422-0067/22/1/166

Internet

https://www.mdpi.com/1422-0067/22/1/166

Similar Items