Spectrum of Germline <i>BRCA1 </i>and<i> BRCA2</i> Variants Identified in 2351 Ovarian and Breast Cancer Patients Referring to a Reference Cancer Hospital of Rome

Spectrum of Germline <i>BRCA1 </i>and<i> BRCA2</i> Variants Identified in 2351 Ovarian and Breast Cancer Patients Referring to a Reference Cancer Hospital of Rome

Pathogenic variants (PVs) carriers in <i>BRCA1 </i>or <i>BRCA2 </i>are associated with an elevated lifetime risk of developing breast cancer (BC) and/or ovarian cancer (OC). The prevalence of <i>BRCA1 </i>and <i>BRCA2 </i>germline alterations is extrem...

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Bibliographic Details
Main Authors: Concetta Santonocito, Roberta Rizza, Ida Paris, Laura De Marchis, Carmela Paolillo, Giordana Tiberi, Giovanni Scambia, Ettore Capoluongo
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cancers
Subjects:
next-generation sequencing
novel variants
<i>BRCA1/2</i>
Online Access:https://www.mdpi.com/2072-6694/12/5/1286

Internet

https://www.mdpi.com/2072-6694/12/5/1286

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