Pharmacokinetic Analysis of 64Cu-ATSM Dynamic PET in Human Xenograft Tumors in Mice

Pharmacokinetic Analysis of 64Cu-ATSM Dynamic PET in Human Xenograft Tumors in Mice

The aim of this study was to evaluate the feasibility to perform voxel-wise kinetic modeling on datasets obtained from tumor-bearing mice that underwent dynamic PET scans with 64Cu-ATSM and extract useful physiological parameters. Methods: Tumor-bearing mice underwent 90-min dynamic PET scans with...

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Bibliographic Details
Main Authors: Fan Li, Jesper Tranekjær Jørgensen, Jacob Madsen, Andreas Kjaer
Format: Article
Language:English
Published: MDPI AG 2015-03-01
Series:Diagnostics
Subjects:
kinetic modeling
64Cu-ATSM
hypoxia
cancer
PET
PET/CT
xenograft tumors
voxel-wise pharmacokinetic analysis
parametric mapping
Online Access:http://www.mdpi.com/2075-4418/5/2/96

Internet

http://www.mdpi.com/2075-4418/5/2/96

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