Next-Generation Sequencing of Antibody Display Repertoires

Next-Generation Sequencing of Antibody Display Repertoires

In vitro selection technology has transformed the development of therapeutic monoclonal antibodies. Using methods such as phage, ribosome, and yeast display, high affinity binders can be selected from diverse repertoires. Here, we review strategies for the next-generation sequencing (NGS) of phage-...

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Bibliographic Details
Main Authors: Romain Rouet, Katherine J. L. Jackson, David B. Langley, Daniel Christ
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
antibody display technology
next-generation sequencing
phage display
antibody libraries
in vitro selection
antibody therapeutics
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00118/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00118/full

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