Construction of Lactobacillus casei ghosts by Holin-mediated inactivation and the potential as a safe and effective vehicle for the delivery of DNA vaccines

Construction of Lactobacillus casei ghosts by Holin-mediated inactivation and the potential as a safe and effective vehicle for the delivery of DNA vaccines

Abstract Background Bacterial ghosts (BGs) are empty bacterial cell envelopes generated by releasing the cellular contents. In this study, a phage infecting Lactobacillus casei ATCC 393 (L. casei 393) was isolated and designated Lcb. We aimed at using L. casei 393 as an antigen delivery system to ex...

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Bibliographic Details
Main Authors: Rui Hou, Muzi Li, Tingting Tang, Ruichong Wang, Yijing Li, Yigang Xu, Lijie Tang, Li Wang, Min Liu, Yanping Jiang, Wen Cui, Xinyuan Qiao
Format: Article
Language:English
Published: BMC 2018-07-01
Series:BMC Microbiology
Subjects:
Bacterial ghost
Lactobacillus casei
DNA vaccine
Phage
Online Access:http://link.springer.com/article/10.1186/s12866-018-1216-6

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http://link.springer.com/article/10.1186/s12866-018-1216-6

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