Stress-Inducible Gene <i>Atf3</i> Dictates a Dichotomous Macrophage Activity in Chemotherapy-Enhanced Lung Colonization

Stress-Inducible Gene <i>Atf3</i> Dictates a Dichotomous Macrophage Activity in Chemotherapy-Enhanced Lung Colonization

Previously, we showed that chemotherapy paradoxically exacerbated cancer cell colonization at the secondary site in a manner dependent on <i>Atf3</i>, a stress-inducible gene, in the non-cancer host cells. Here, we present evidence that this phenotype is established at an early stage of...

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Bibliographic Details
Main Authors: Justin D. Middleton, Jared Fehlman, Subhakeertana Sivakumar, Daniel G. Stover, Tsonwin Hai
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
chemotherapy
breast cancer metastasis
lung colonization
macrophage dichotomy
stress response
<i>Atf3</i>
Online Access:https://www.mdpi.com/1422-0067/22/14/7356

Internet

https://www.mdpi.com/1422-0067/22/14/7356

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