Yes-Associated Protein (Yap) Is Up-Regulated in Heart Failure and Promotes Cardiac Fibroblast Proliferation

Yes-Associated Protein (Yap) Is Up-Regulated in Heart Failure and Promotes Cardiac Fibroblast Proliferation

Left ventricular (LV) heart failure (HF) is a significant and increasing cause of death worldwide. HF is characterized by myocardial remodeling and excessive fibrosis. Transcriptional co-activator Yes-associated protein (Yap), the downstream effector of HIPPO signaling pathway, is an essential facto...

Full description

Bibliographic Details
Main Authors: Maryam Sharifi-Sanjani, Mariah Berman, Dmitry Goncharov, Mohammad Alhamaydeh, Theodore Guy Avolio, Jeffrey Baust, Baojun Chang, Ahasanul Kobir, Mark Ross, Claudette St. Croix, Seyed Mehdi Nouraie, Charles F. McTiernan, Christine S. Moravec, Elena Goncharova, Imad Al Ghouleh
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
Yap
cardiac fibroblasts
proliferation
heart failure
mTOR
Online Access:https://www.mdpi.com/1422-0067/22/11/6164

Internet

https://www.mdpi.com/1422-0067/22/11/6164

Similar Items