Monomerization of ALK Fusion Proteins as a Therapeutic Strategy in ALK-Rearranged Non-small Cell Lung Cancers

Monomerization of ALK Fusion Proteins as a Therapeutic Strategy in ALK-Rearranged Non-small Cell Lung Cancers

Objective: Oncogenic echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) (EML4-ALK) fusion proteins found in non-small cell lung cancers (NSCLC) are constitutively phosphorylated and activated by dimerization via the coiled-coil domain (cc) within EML4. Here, we...

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Bibliographic Details
Main Authors: Noriko Hirai, Takaaki Sasaki, Shunsuke Okumura, Yoshinori Minami, Shinichi Chiba, Yoshinobu Ohsaki
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Oncology
Subjects:
coiled-coil domain
EML4-ALK rearrangement
lung cancer
oncogene fusion proteins
peptide synthesis
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00419/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.00419/full

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