Phosphate Binding with Sevelamer Preserves Mechanical Competence of Bone Despite Acidosis in Advanced Experimental Renal Insufficiency.

Phosphate Binding with Sevelamer Preserves Mechanical Competence of Bone Despite Acidosis in Advanced Experimental Renal Insufficiency.

INTRODUCTION:Phosphate binding with sevelamer can ameliorate detrimental histomorphometric changes of bone in chronic renal insufficiency (CRI). Here we explored the effects of sevelamer-HCl treatment on bone strength and structure in experimental CRI. METHODS:Forty-eight 8-week-old rats were assign...

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Main Authors: Jarkko Jokihaara, Ilkka H Pörsti, Harri Sievänen, Peeter Kööbi, Pekka Kannus, Onni Niemelä, Russell T Turner, Urszula T Iwaniec, Teppo L N Järvinen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5033583?pdf=render

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http://europepmc.org/articles/PMC5033583?pdf=render

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