Generation of an Oncolytic Herpes Simplex Virus 1 Expressing Human MelanA

Generation of an Oncolytic Herpes Simplex Virus 1 Expressing Human MelanA

Robust anti-tumor immunity requires innate as well as adaptive immune responses. We have shown that plasmacytoid dendritic cells develop killer cell-like activity in melanoma cell cocultures after exposure to the infectious but replication-deficient herpes simplex virus 1 (HSV-1) d106S. To combine t...

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Bibliographic Details
Main Authors: Jan B. Boscheinen, Sabrina Thomann, David M. Knipe, Neal DeLuca, Beatrice Schuler-Thurner, Stefanie Gross, Jan Dörrie, Niels Schaft, Christian Bach, Anette Rohrhofer, Melanie Werner-Klein, Barbara Schmidt, Philipp Schuster
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
vaccine
oncolytic viruses
malignant melanoma
herpes virus
cytotoxic T cell response
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00002/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00002/full

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