A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin2α-induced corpus luteum regression

A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin2α-induced corpus luteum regression

Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) normally signals to necroptosis by phosphorylating MLKL. We report here that when the cellular RIPK3 chaperone Hsp90/CDC37 level is low, RIPK3 also signals to apoptosis. The apoptotic function of RIPK3 requires phosphorylation of the ser...

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Bibliographic Details
Main Authors: Dianrong Li, Jie Chen, Jia Guo, Lin Li, Gaihong Cai, She Chen, Jia Huang, Hui Yang, Yinhua Zhuang, Fengchao Wang, Xiaodong Wang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-05-01
Series:eLife
Subjects:
RIPK3
necroptosis
apoptosis
ovary
prostaglandins
Caspase-8
Online Access:https://elifesciences.org/articles/67409

Internet

https://elifesciences.org/articles/67409

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