Irradiation Haematopoiesis Recovery Orchestrated by IL-12/IL-12Rβ1/TYK2/STAT3-Initiated Osteogenic Differentiation of Mouse Bone Marrow-Derived Mesenchymal Stem Cells

Irradiation Haematopoiesis Recovery Orchestrated by IL-12/IL-12Rβ1/TYK2/STAT3-Initiated Osteogenic Differentiation of Mouse Bone Marrow-Derived Mesenchymal Stem Cells

PurposeRepairing the irradiation-induced osteogenic differentiation injury of bone marrow mesenchymal stem cells (BM-MSCs) is beneficial to recovering haematopoiesis injury in radiotherapy; however, its mechanism is elusive. Our study aimed to help meet the needs of understanding the effects of radi...

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Bibliographic Details
Main Authors: Fengjie Li, Rong Zhang, Changpeng Hu, Qian Ran, Yang Xiang, Lixin Xiang, Li Chen, Yang Yang, Shengwen Calvin Li, Gang Zhang, Zhongjun Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
irradiation
haematopoiesis
recovery
osteogenesis
IL-12
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.729293/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.729293/full

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