Physical Factors Affecting Plasmid DNA Compaction in Stearylamine-Containing Nanoemulsions Intended for Gene Delivery

Physical Factors Affecting Plasmid DNA Compaction in Stearylamine-Containing Nanoemulsions Intended for Gene Delivery

Cationic lipids have been used in the development of non-viral gene delivery systems as lipoplexes. Stearylamine, a cationic lipid that presents a primary amine group when in solution, is able to compact genetic material by electrostatic interactions. In dispersed systems such as nanoemulsions this...

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Bibliographic Details
Main Authors: Eryvaldo Socrates Tabosa do Egito, Francisco Alexandrino, Lourena Mafra Verissimo, Lucymara Fassarella Agnez-Lima, Lucila Carmem Monte Egito, André Leandro Silva, Anselmo Gomes de Oliveira
Format: Article
Language:English
Published: MDPI AG 2012-06-01
Series:Pharmaceuticals
Subjects:
gene therapy
stearylamine
cationic lipid nanoemulsions
Online Access:http://www.mdpi.com/1424-8247/5/6/643

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http://www.mdpi.com/1424-8247/5/6/643

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