Dirichlet multinomial mixtures: generative models for microbial metagenomics.

We introduce Dirichlet multinomial mixtures (DMM) for the probabilistic modelling of microbial metagenomics data. This data can be represented as a frequency matrix giving the number of times each taxa is observed in each sample. The samples have different size, and the matrix is sparse, as communit...

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Bibliographic Details
Main Authors: Ian Holmes, Keith Harris, Christopher Quince
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3272020?pdf=render