Interleukin-7 and Toll-like receptor 7 induce synergistic B cell and T cell activation.

Interleukin-7 and Toll-like receptor 7 induce synergistic B cell and T cell activation.

OBJECTIVES: To investigate the potential synergy of IL-7-driven T cell-dependent and TLR7-mediated B cell activation and to assess the additive effects of monocyte/macrophages in this respect. METHODS: Isolated CD19 B cells and CD4 T cells from healthy donors were co-cultured with TLR7 agonist (TLR7...

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Bibliographic Details
Main Authors: Angela Bikker, Aike A Kruize, Kim M G van der Wurff-Jacobs, Rogier P Peters, Marije Kleinjan, Frank Redegeld, Wilco de Jager, Floris P J G Lafeber, Joël A G van Roon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3989236?pdf=render

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http://europepmc.org/articles/PMC3989236?pdf=render

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