A high throughput screen identifies potent and selective inhibitors to human epithelial 15-lipoxygenase-2.

A high throughput screen identifies potent and selective inhibitors to human epithelial 15-lipoxygenase-2.

Lipoxygenase (LOX) enzymes catalyze the hydroperoxidation of arachidonic acid and other polyunsaturated fatty acids to hydroxyeicosatetraenoic acids with varying positional specificity to yield important biological signaling molecules. Human epithelial 15-lipoxygenase-2 (15-LOX-2) is a highly specif...

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Bibliographic Details
Main Authors: J Brian Jameson, Auric Kantz, Lena Schultz, Chakrapani Kalyanaraman, Matthew P Jacobson, David J Maloney, Ajit Jadhav, Anton Simeonov, Theodore R Holman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4128814?pdf=render

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http://europepmc.org/articles/PMC4128814?pdf=render

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