Alternative Complement Pathway Is Activated and Associated with Galactose-Deficient IgA1 Antibody in IgA Nephropathy Patients

Alternative Complement Pathway Is Activated and Associated with Galactose-Deficient IgA1 Antibody in IgA Nephropathy Patients

BackgroundGalactose-deficient IgA1 (Gd-IgA1) and alternative complement pathway activation are considered to be involved in the pathogenesis of IgA nephropathy (IgAN). Nevertheless, the relationships between alternative pathway activation and disease activity or Gd-IgA1 level remains unclear.Methods...

Full description

Bibliographic Details
Main Authors: Yen-Ling Chiu, Wei-Chou Lin, Kai-Hsiang Shu, Yi-Wen Fang, Fan-Chi Chang, Yu-Hsiang Chou, Ching-Fang Wu, Wen-Chih Chiang, Shuei-Liong Lin, Yung-Ming Chen, Ming-Shiou Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
complement
C5a
factor B
galactose-deficient IgA1
IgA nephropathy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.638309/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.638309/full

Similar Items