Analysis of Global Collection of Group A Streptococcus Genomes Reveals that the Majority Encode a Trio of M and M-Like Proteins

Analysis of Global Collection of Group A Streptococcus Genomes Reveals that the Majority Encode a Trio of M and M-Like Proteins

While the GAS M protein has been the leading vaccine target for decades, the bacteria encode many other virulence factors of interest for vaccine development. In this work, we show that emm-like genes are encoded in a remarkable majority of GAS genomes and expressed at a level similar to that for th...

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Bibliographic Details
Main Authors: Hannah R. Frost, Mark R. Davies, Valérie Delforge, Dalila Lakhloufi, Martina Sanderson-Smith, Velusamy Srinivasan, Andrew C. Steer, Mark J. Walker, Bernard Beall, Anne Botteaux, Pierre R. Smeesters
Format: Article
Language:English
Published: American Society for Microbiology 2020-01-01
Series:mSphere
Subjects:
streptococcus pyogenes
mga regulon
m-like proteins
global gas diversity
Online Access:https://doi.org/10.1128/mSphere.00806-19

Internet

https://doi.org/10.1128/mSphere.00806-19

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