Early Trypanosoma cruzi Infection Triggers mTORC1-Mediated Respiration Increase and Mitochondrial Biogenesis in Human Primary Cardiomyocytes

Early Trypanosoma cruzi Infection Triggers mTORC1-Mediated Respiration Increase and Mitochondrial Biogenesis in Human Primary Cardiomyocytes

Chagasic chronic cardiomyopathy is one of the most frequent and severe manifestations of Chagas disease, caused by the parasite Trypanosoma cruzi. The pathogenic and biochemical mechanisms responsible for cardiac lesions remain not completely understood, although it is clear that hypertrophy and sub...

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Bibliographic Details
Main Authors: M. Gabriela Libisch, Paula Faral-Tello, Nisha J. Garg, Rafael Radi, Lucía Piacenza, Carlos Robello
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Microbiology
Subjects:
Chagas disease
chronic chagasic cardiopathy
host–pathogen
early response to infection
mitochondrial function
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01889/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.01889/full

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