Inhibitory effect of anti-malarial agents on the expression of proinflammatory chemokines via Toll-like receptor 3 signaling in human glomerular endothelial cells

Inhibitory effect of anti-malarial agents on the expression of proinflammatory chemokines via Toll-like receptor 3 signaling in human glomerular endothelial cells

Objective Although anti-malarial agents, chloroquine (CQ) and hydroxychloroquine (HCQ) are currently used for the treatment of systemic lupus erythematosus, their efficacy for lupus nephritis (LN) remains unclear. Given that upregulation of glomerular Toll-like receptor 3 (TLR3) signaling plays a pi...

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Bibliographic Details
Main Authors: Riko Sato, Tadaatsu Imaizumi, Tomomi Aizawa, Shojiro Watanabe, Koji Tsugawa, Shogo Kawaguchi, Kazuhiko Seya, Tomoh Matsumiya, Hiroshi Tanaka
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Renal Failure
Subjects:
chloroquine
glomerular endothelial cells
hydroxychloroquine
lupus nephritis
toll-like receptor 3
Online Access:http://dx.doi.org/10.1080/0886022X.2021.1908901

Internet

http://dx.doi.org/10.1080/0886022X.2021.1908901

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