Protective efficacy of the anti-HIV broadly neutralizing antibody PGT121 in the context of semen exposure

Protective efficacy of the anti-HIV broadly neutralizing antibody PGT121 in the context of semen exposure

Background: HIV-1 infections occur following viral exposure at anogenital mucosal surfaces in the presence of semen. Semen contains immunosuppressive and pro-inflammatory factors. Semen from HIV-1-infected donors contains anti-HIV-1 antibodies. We assessed if passively infused anti-HIV-1 neutralizin...

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Bibliographic Details
Main Authors: Matthew S. Parsons, Anne B. Kristensen, Kevin J. Selva, Wen Shi Lee, Thakshila Amarasena, Robyn Esterbauer, Adam K. Wheatley, Benjamin R. Bavinton, Anthony D. Kelleher, Andrew E. Grulich, Georges Khoury, Jennifer A. Juno, Stephen J. Kent
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:EBioMedicine
Subjects:
HIV-1
Broadly neutralizing antibodies
Semen
Fc-dependent functions
Online Access:http://www.sciencedirect.com/science/article/pii/S235239642100311X

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http://www.sciencedirect.com/science/article/pii/S235239642100311X

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