Coordinate Regulation of Cholesterol and Bile Acid Metabolism by the Clock Modifier Nobiletin in Metabolically Challenged Old Mice

Coordinate Regulation of Cholesterol and Bile Acid Metabolism by the Clock Modifier Nobiletin in Metabolically Challenged Old Mice

Cholesterol and bile acid (BA) homeostasis plays a central role in systemic metabolism. Accumulating evidence suggests a key regulatory function of the circadian clock, our biological timer, in lipid metabolism, particularly cholesterol and bile acid flux. Previously, we showed that Nobiletin (NOB),...

Full description

Bibliographic Details
Main Authors: Kazunari Nohara, Travis Nemkov, Angelo D’Alessandro, Seung-Hee Yoo, Zheng Chen
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
circadian clock modifier
Nobiletin
cholesterol and bile acid homeostasis
gut microbiota
liver
gene expression
aging
high-fat feeding
Online Access:https://www.mdpi.com/1422-0067/20/17/4281

Internet

https://www.mdpi.com/1422-0067/20/17/4281

Similar Items