The Potential of the FSP1cre-<i>Pparb/d<sup>−/−</sup></i> Mouse Model for Studying Juvenile NAFLD

The Potential of the FSP1cre-<i>Pparb/d<sup>−/−</sup></i> Mouse Model for Studying Juvenile NAFLD

Non-alcoholic fatty liver disease (NAFLD) can progress from steatosis to non-alcoholic steatohepatitis (NASH) characterized by liver inflammation, possibly leading to cirrhosis and hepatocellular carcinoma (HCC). Mice with impaired macrophage activation, when fed a high-fat diet, develop severe NASH...

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Bibliographic Details
Main Authors: Jiapeng Chen, Yan Zhuang, Ming Keat Sng, Nguan Soon Tan, Walter Wahli
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
<i>pparb/d</i>
fsp1
lipid metabolism
steatosis
fatty acid β-oxidation
fatty acid synthesis and triglyceride synthesis
Online Access:https://www.mdpi.com/1422-0067/20/20/5115

Internet

https://www.mdpi.com/1422-0067/20/20/5115

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