Phosphodiesterase Type 5 Inhibitors Synergize Vincristine in Killing Castration-Resistant Prostate Cancer Through Amplifying Mitotic Arrest Signaling

Phosphodiesterase Type 5 Inhibitors Synergize Vincristine in Killing Castration-Resistant Prostate Cancer Through Amplifying Mitotic Arrest Signaling

Combination therapies that display cancer-killing activities through either coexistent targeting of several cellular factors or more efficient suppression of a specific pathway are generally used in cancer treatment. Sildenafil, a specific phosphodiesterase type 5 (PDE5) inhibitor, has been suggeste...

Full description

Bibliographic Details
Main Authors: Jui-Ling Hsu, Wohn-Jenn Leu, Lih-Ching Hsu, Chen-Hsun Ho, Shih-Ping Liu, Jih-Hwa Guh
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Oncology
Subjects:
sildenafil
vincristine
castration-resistant prostate cancer
spindle assembly checkpoint
kinetochore tension
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01274/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.01274/full

Similar Items