Impaired Alignment of Bone Matrix Microstructure Associated with Disorganized Osteoblast Arrangement in Malignant Melanoma Metastasis

Impaired Alignment of Bone Matrix Microstructure Associated with Disorganized Osteoblast Arrangement in Malignant Melanoma Metastasis

Malignant melanoma favors spreading to bone, resulting in a weakened bone with a high fracture risk. Here, we revealed the disorganized alignment of apatite crystals in the bone matrix associated with the homing of cancer cells by developing an artificially controlled ex vivo melanoma bone metastasi...

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Bibliographic Details
Main Authors: Aira Matsugaki, Yumi Kimura, Ryota Watanabe, Fumihito Nakamura, Ryo Takehana, Takayoshi Nakano
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Biomolecules
Subjects:
malignant melanoma
ex vivo metastasis model
bone tissue microstructure
osteoblast
Online Access:https://www.mdpi.com/2218-273X/11/2/131

Internet

https://www.mdpi.com/2218-273X/11/2/131

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