Zidovudine ameliorates pathology in the mouse model of Duchenne muscular dystrophy via P2RX7 purinoceptor antagonism

Zidovudine ameliorates pathology in the mouse model of Duchenne muscular dystrophy via P2RX7 purinoceptor antagonism

Abstract Duchenne muscular dystrophy (DMD) is the most common inherited muscle disorder that causes severe disability and death of young men. This disease is characterized by progressive muscle degeneration aggravated by sterile inflammation and is also associated with cognitive impairment and low b...

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Bibliographic Details
Main Authors: Rasha Al-Khalidi, Chiara Panicucci, Paul Cox, Natalia Chira, Justyna Róg, Christopher N. J. Young, Rhiannon E. McGeehan, Kameshwari Ambati, Jayakrishna Ambati, Krzysztof Zabłocki, Elisabetta Gazzerro, Stephen Arkle, Claudio Bruno, Dariusz C. Górecki
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Acta Neuropathologica Communications
Subjects:
AZT
Duchenne muscular dystrophy
eATP
mdx
Purinergic receptors
P2RX7
Online Access:http://link.springer.com/article/10.1186/s40478-018-0530-4

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http://link.springer.com/article/10.1186/s40478-018-0530-4

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