Cholesterol depletion reduces aggregation of amyloid-beta peptide in hippocampal neurons
A key event in the pathogenesis of Alzheimer's disease is the conversion of soluble amyloid Aβ-peptide into toxic aggregates. Here, we studied the effect of cholesterol depletion on the formation of insoluble Aβ. We found that reduction of neuronal cholesterol by ∼25% reduced the neuronal forma...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2006-09-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S096999610600101X |