Cholesterol depletion reduces aggregation of amyloid-beta peptide in hippocampal neurons

Cholesterol depletion reduces aggregation of amyloid-beta peptide in hippocampal neurons

A key event in the pathogenesis of Alzheimer's disease is the conversion of soluble amyloid Aβ-peptide into toxic aggregates. Here, we studied the effect of cholesterol depletion on the formation of insoluble Aβ. We found that reduction of neuronal cholesterol by ∼25% reduced the neuronal forma...

Full description

Bibliographic Details
Main Authors: Anja Schneider, Walter Schulz-Schaeffer, Tobias Hartmann, Jörg B. Schulz, Mikael Simons
Format: Article
Language:English
Published: Elsevier 2006-09-01
Series:Neurobiology of Disease
Subjects:
Cholesterol
Aggregation
Hippocampal neurons
Aβ
Oligomers
Alzheimer's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S096999610600101X
Description
Summary:A key event in the pathogenesis of Alzheimer's disease is the conversion of soluble amyloid Aβ-peptide into toxic aggregates. Here, we studied the effect of cholesterol depletion on the formation of insoluble Aβ. We found that reduction of neuronal cholesterol by ∼25% reduced the neuronal formation of insoluble Aβ without affecting the secretion of soluble Aβ. Moreover, we demonstrate that Aβ-oligomers from Alzheimer's disease brains associate with a detergent-resistant membrane fraction in a cholesterol-dependent manner. These results suggest a key role for cholesterol in aggregation of Aβ.
ISSN:1095-953X

Similar Items