Interplay between Histone and DNA Methylation Seen through Comparative Methylomes in Rare Mendelian Disorders

Interplay between Histone and DNA Methylation Seen through Comparative Methylomes in Rare Mendelian Disorders

DNA methylation (DNAme) profiling is used to establish specific biomarkers to improve the diagnosis of patients with inherited neurodevelopmental disorders and to guide mutation screening. In the specific case of mendelian disorders of the epigenetic machinery, it also provides the basis to infer me...

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Bibliographic Details
Main Authors: Guillaume Velasco, Damien Ulveling, Sophie Rondeau, Pauline Marzin, Motoko Unoki, Valérie Cormier-Daire, Claire Francastel
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
rare diseases
DNA methylation profiling
histone methylation
biomarkers
epigenetic crosstalks
Online Access:https://www.mdpi.com/1422-0067/22/7/3735

Internet

https://www.mdpi.com/1422-0067/22/7/3735

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