Imaging carbonic anhydrase IX as a method for monitoring hypoxia-related radioresistance in preclinical head and neck cancer models

Imaging carbonic anhydrase IX as a method for monitoring hypoxia-related radioresistance in preclinical head and neck cancer models

Background and purpose: Tumor hypoxia is an important cause of radioresistance and is associated with poor outcome.SPECT (Single-photon emission computed tomography) imaging enables visualizing tumor characteristics. We investigated the SPECT-radiotracer [111In]-girentuximab-F(ab’)2 to image Carboni...

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Bibliographic Details
Main Authors: Fokko J. Huizing, Bianca A.W. Hoeben, Jasper Lok, Otto C. Boerman, Sandra Heskamp, Johan Bussink
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Physics and Imaging in Radiation Oncology
Subjects:
Head and neck xenografts
Hypoxia
CAIX imaging
Functional imaging
Girentuximab
Atovaquone
Online Access:http://www.sciencedirect.com/science/article/pii/S240563162100049X

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http://www.sciencedirect.com/science/article/pii/S240563162100049X

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