Serial MRI studies over 12 months using manual and atlas-based region of interest in patients with amyotrophic lateral sclerosis
Abstract Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by loss of upper and lower motor neurons. There is a need for an imaging biomarker to track disease progression. Previously, magnetic resonance imaging (MRI) has shown loss of grey and white matter i...
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doaj-dd310c55de974d2fbfe89489807bc9c12020-11-25T03:15:49ZengBMCBMC Medical Imaging1471-23422020-08-0120111010.1186/s12880-020-00489-wSerial MRI studies over 12 months using manual and atlas-based region of interest in patients with amyotrophic lateral sclerosisAshwag R. Alruwaili0Kerstin Pannek1Robert D. Henderson2Marcus Gray3Nyoman D. Kurniawan4Pamela A. McCombe5The University of Queensland, Centre for Clinical ResearchAustralian E–Health Research Centre, CSIROSchool of Medicine, The University of QueenslandCentre for Advanced Imaging, The University of QueenslandCentre for Advanced Imaging, The University of QueenslandThe University of Queensland, Centre for Clinical ResearchAbstract Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by loss of upper and lower motor neurons. There is a need for an imaging biomarker to track disease progression. Previously, magnetic resonance imaging (MRI) has shown loss of grey and white matter in the brain of patients with ALS compared to controls. We performed serial diffusion tractography imaging (DTI) study of patients with ALS looking for changes over time. Methods On all subjects (n = 15), we performed three MRI studies at 6 month intervals. DTI changes were assessed with tract-based spatial statistics (TBSS) and region of interest (ROI) studies. Cortic-spinal tract (CST) was selected for our ROI at the upper level; the posterior limb of internal capsule (PLIC), and a lower level in the pons. Results There was no significant change in DTI measures over 12 months of observation. Better correlation of manual and atlas-based ROI methods was found in the posterior limb of the internal capsule than the pons. Conclusion While previous DTI studies showed significant differences between ALS subjects and controls, within individual subjects there is little evidence of progression over 12 months. This suggests that DTI is not a suitable biomarker to assess disease progression in ALS.http://link.springer.com/article/10.1186/s12880-020-00489-wAmyotrophic lateral sclerosisALSMotor neuron diseaseMNDDiffusion tensor imagingDTI |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ashwag R. Alruwaili Kerstin Pannek Robert D. Henderson Marcus Gray Nyoman D. Kurniawan Pamela A. McCombe |
spellingShingle |
Ashwag R. Alruwaili Kerstin Pannek Robert D. Henderson Marcus Gray Nyoman D. Kurniawan Pamela A. McCombe Serial MRI studies over 12 months using manual and atlas-based region of interest in patients with amyotrophic lateral sclerosis BMC Medical Imaging Amyotrophic lateral sclerosis ALS Motor neuron disease MND Diffusion tensor imaging DTI |
author_facet |
Ashwag R. Alruwaili Kerstin Pannek Robert D. Henderson Marcus Gray Nyoman D. Kurniawan Pamela A. McCombe |
author_sort |
Ashwag R. Alruwaili |
title |
Serial MRI studies over 12 months using manual and atlas-based region of interest in patients with amyotrophic lateral sclerosis |
title_short |
Serial MRI studies over 12 months using manual and atlas-based region of interest in patients with amyotrophic lateral sclerosis |
title_full |
Serial MRI studies over 12 months using manual and atlas-based region of interest in patients with amyotrophic lateral sclerosis |
title_fullStr |
Serial MRI studies over 12 months using manual and atlas-based region of interest in patients with amyotrophic lateral sclerosis |
title_full_unstemmed |
Serial MRI studies over 12 months using manual and atlas-based region of interest in patients with amyotrophic lateral sclerosis |
title_sort |
serial mri studies over 12 months using manual and atlas-based region of interest in patients with amyotrophic lateral sclerosis |
publisher |
BMC |
series |
BMC Medical Imaging |
issn |
1471-2342 |
publishDate |
2020-08-01 |
description |
Abstract Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by loss of upper and lower motor neurons. There is a need for an imaging biomarker to track disease progression. Previously, magnetic resonance imaging (MRI) has shown loss of grey and white matter in the brain of patients with ALS compared to controls. We performed serial diffusion tractography imaging (DTI) study of patients with ALS looking for changes over time. Methods On all subjects (n = 15), we performed three MRI studies at 6 month intervals. DTI changes were assessed with tract-based spatial statistics (TBSS) and region of interest (ROI) studies. Cortic-spinal tract (CST) was selected for our ROI at the upper level; the posterior limb of internal capsule (PLIC), and a lower level in the pons. Results There was no significant change in DTI measures over 12 months of observation. Better correlation of manual and atlas-based ROI methods was found in the posterior limb of the internal capsule than the pons. Conclusion While previous DTI studies showed significant differences between ALS subjects and controls, within individual subjects there is little evidence of progression over 12 months. This suggests that DTI is not a suitable biomarker to assess disease progression in ALS. |
topic |
Amyotrophic lateral sclerosis ALS Motor neuron disease MND Diffusion tensor imaging DTI |
url |
http://link.springer.com/article/10.1186/s12880-020-00489-w |
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