A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes.

A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes.

Myristoylation is a lipid modification involving the addition of a 14-carbon unsaturated fatty acid, myristic acid, to the N-terminal glycine of a subset of proteins, a modification that promotes their binding to cell membranes for varied biological functions. The process is catalyzed by myristoyl-C...

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Bibliographic Details
Main Authors: Brendan D Galvin, Zhiru Li, Estelle Villemaine, Catherine B Poole, Melissa S Chapman, Michael P Pollastri, Paul G Wyatt, Clotilde K S Carlow
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-09-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4154664?pdf=render

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http://europepmc.org/articles/PMC4154664?pdf=render

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