Optimal two-stage designs based on restricted mean survival time for a single-arm study
Restricted mean survival time is an alternative measure of treatment effect to hazard ratio in clinical trials with time-to-event outcome. The current methods have been focused on one-stage designs. In this article, we propose optimal two-stage designs for a single-arm study with the smallest expect...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-03-01
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| Series: | Contemporary Clinical Trials Communications |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S245186542100034X |