Intestinal Barrier Dysfunction Exacerbates Neuroinflammation via the TLR4 Pathway in Mice With Heart Failure

Intestinal Barrier Dysfunction Exacerbates Neuroinflammation via the TLR4 Pathway in Mice With Heart Failure

AimsThe present study aimed to investigate alterations in neuroinflammation after heart failure (HF) and explore the potential mechanisms.MethodsMale wild-type (WT) and Toll-like receptor 4 (TLR4)-knockout (KO) mice were subjected to sham operation or ligation of the left anterior descending coronar...

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Bibliographic Details
Main Authors: Jun-Yu Huo, Wan-Ying Jiang, Ting Yin, Hai Xu, Yi-Ting Lyu, Yuan-Yuan Chen, Meng Chen, Jie Geng, Zhi-Xin Jiang, Qi-Jun Shan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Physiology
Subjects:
heart failure
neuroinflammation
intestinal barrier
lipopolysaccharide
TLR4
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.712338/full

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https://www.frontiersin.org/articles/10.3389/fphys.2021.712338/full

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