The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences

The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences

Summary: The GluN2 subtype (2A versus 2B) determines biophysical properties and signaling of forebrain NMDA receptors (NMDARs). During development, GluN2A becomes incorporated into previously GluN2B-dominated NMDARs. This “switch” is proposed to be driven by distinct features of GluN2 cytoplasmic C-...

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Bibliographic Details
Main Authors: Sean McKay, Tomás J. Ryan, Jamie McQueen, Tim Indersmitten, Katie F.M. Marwick, Philip Hasel, Maksym V. Kopanitsa, Paul S. Baxter, Marc-André Martel, Peter C. Kind, David J.A. Wyllie, Thomas J. O’Dell, Seth G.N. Grant, Giles E. Hardingham, Noboru H. Komiyama
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718315602

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http://www.sciencedirect.com/science/article/pii/S2211124718315602

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